The last NSRG general body meeting of the school year was held on Thursday, May 21st, 2015 in the D3 Classroom. Guest speaker Dr. Richard Watt (BYU) came to talk to the students about his current research projects and how they are applicable to the dental profession.
Iron man: Superhero or Menace? Dr. Richard Watt The majority of chronic diseases facing the medical field today involve inflammation and oxidative stress. Intimately connected to these diseases is free iron, the catalyst for producing reactive oxygen species (ROS) that cause oxidative stress and enhance inflammation. Viewing chronic inflammatory disorders with oxidative stress from the free iron perspective has given new perspective and understanding to how oxidative stress is initiated. I will discuss a journey our lab has taken to understand how free iron forms. As we have applied our model we have found applications for studying oxidative stress: 1) in serum studying Transferrin and Non-Transferrin Bound Iron; 2) in cells studying the labile iron pools interaction with ferritin; and 3) in anemia of chronic inflammation and the role of the hormone hepcidin. Remarkably these studies have blossomed into applying our knowledge to other diseases known to have iron dysregulation problems including Alzheimer’s Disease, Parkinson’s Disease, Periodontitis and Cancer. I will discuss the collaboration we are establishing with Roseman University to initially focus on Periodontitis and oral cancer but with the hope to expand our studies to these other diseases. Comments are closed.
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